Tetracycline (Achromycin and Sumycin)

Tetracycline Review

Use Tetracycline to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.

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Tetracycline Drug Class and Mechanism

It works by inhibiting action of the prokaryotic 30S ribosome, by binding aminoacyl-tRNA. However, bacteria strains can aquire resistance against tetracycline and its derivates by encoding a resistance operon.

In eukaryotic cells, toxicity may be result of inactivation of mitochondrial 30S ribosomes.

Tetracycline Uses

Take Tetracycline tablets or capsules by mouth. Follow the directions on the prescription label. Take Tetracycline 1 hour before or at least 2 hours after eating. Swallow tablets or capsules whole with a full glass of water; take tablets or capsules in an upright or sitting position. Taking a sip of water first, before taking the tablets or capsules, may help you swallow them. If possible take bedtime doses at least 10 minutes before lying down. It is best to take Tetracycline without food, but if it upsets your stomach take it with food. Avoid having dairy products, such as yogurt, milk, or cheese with your medicine; they can reduce the effect of Tetracycline. Take your doses at regular intervals. Do not take your medicine more often than directed. Finish the full course prescribed by your prescriber or health care professional even if you think your condition is better. Do not stop taking except on your prescriber's advice. Contact your pediatrician or health care professional regarding the use of Tetracycline in children. Special care may be needed.

Tetracycline Side Effects

Are as those of the tetracycline antibiotics group: Can stain developing teeth (even when taken by the mother during pregnancy) Inactivated by Ca2+ ion, not advised to be taken with milk or yogurt Inactivated by aluminium, iron and zinc, not to be taken at the same time as indigestion remedies Inactivated by common antacids and over the counter heart burn medicines. Skin photosensitivity, not advised to be exposed to the Sun or intense light Drug-induced lupus, and hepatitis Tinnitus When used for acne vulgaris, skin can be extremely dry and flaky if overused May interfere with methotrexate by displacing it from the various protein binding sites.

Tetracycline Pregnancy

Tetracycline Overdose

In case of overdosage, treat symptomatically and institute sup- portive measures.

Tetracycline More Information

If you are undergoing long-term therapy, periodic laboratory evaluation of organ system function, including renal, hepatic, and hematopoietic systems, should be performed.